Overall, we identified 38 relevant papers on the use of probiotics. We excluded 28 of the 38 papers three single blind trials,7 9 two letters on experimental use of probiotics, 10 11 three case series pandora essence,12 14 and three trials originally done for another indication.15 17 We also excluded five trials that studied only traveller’s diarrhoea 3 18 21 and 12 trials that studied infectious diarrhoea. 4 6 22 30 Of the latter, one trial was in normal subjects exposed to a bacterial challenge,4 one in patients infected with HIV,6 nine in children with diarrhoea of mixed causes, and one in adults with diarrhoea of mixed causes.26 We excluded the trial in HIV patients because the results may not be generalised to other patients.6.
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