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(a) Two color direct fluorescence microscopy on myoblast cultures treated with TALENs and IDLV donor DNA. Owing to a bi cistronic expression unit, cells transduced with the TALEN encoding AdVs become tagged with the DsRedEx2.1 reporter. Upper panel, diagram of PCR assays for detecting HR derived (jT) and (jC) IDLV DNA AAVS1 junctions and head to tail IDLV DNA concatemers (jH T).

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